Product Usage: This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals. It is not approved for human or animal consumption. Misuse, misbranding, or mislabeling as a drug, food, or cosmetic is strictly prohibited. All information provided is for educational purposes only.
ARA-290
£65.99
In stock
ARA-290 is a synthetic peptide derived from the tertiary structure of erythropoietin (EPO), a hormone primarily known for its role in red blood cell production. This innovative peptide has been designed to harness the tissue-protective and repair properties of EPO without stimulating erythropoiesis. ARA-290 has shown remarkable potential in preclinical and clinical studies for its ability to reduce inflammation, promote healing, and protect various organs and tissues from damage. Requires reconstitution before use.
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Size:
12 mg
Ships tomorrow morning if ordered by 2PM UTC
Free international delivery within 1-3 business days on orders over £250, with a tracking number provided.
Third party tested
FREE Bacteriostatic Water
For every £75 you spend, get 1 FREE bottle of Bacteriostatic Water to reconstitute your peptides.
ARA-290
£65.99
In stock
Buy 3+ for £50 each and save 5%
Buy 5+ for £50 each and save 8%
Buy 10+ for £50 each and save 10%
Loading stock...
Size:
12 mg
Ships tomorrow morning if ordered by 2PM UTC
Free international delivery within 1-3 business days on orders over £250, with a tracking number provided.
Third party tested
FREE Bacteriostatic Water
For every £75 you spend, get 1 FREE bottle of Bacteriostatic Water to reconstitute your peptides.
ARA-290 is a synthetic peptide derived from the tertiary structure of erythropoietin (EPO), a hormone primarily known for its role in red blood cell production. This innovative peptide has been designed to harness the tissue-protective and repair properties of EPO without stimulating erythropoiesis. ARA-290 has shown remarkable potential in preclinical and clinical studies for its ability to reduce inflammation, promote healing, and protect various organs and tissues from damage. Requires reconstitution before use.
Product Usage: This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals. It is not approved for human or animal consumption. Misuse, misbranding, or mislabeling as a drug, food, or cosmetic is strictly prohibited. All information provided is for educational purposes only.
Characteristics
Molecular Formula
C225H348N60O68
CAS Number
2023788-19-2
Molar Mass
5047.61g/mol
Amino Acid
Sequence
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
Synonyms
LY3298176
Solubility
Water-soluble |
Organoleptic Profile
White to off-white powder
Composition
Lyophilized powder - requires reconstitution
How does ARA-290 work?
ARA-290 exerts its effects by selectively activating the innate repair receptor (IRR), a heteromeric complex composed of EPO receptor (EPOR) and β common receptor (βcR) subunits. This specific interaction triggers a cascade of signaling events that lead to anti-inflammatory, tissue-protective, and repair-promoting effects. ARA-290 has been shown to modulate the immune response by reducing the production of pro-inflammatory cytokines and increasing the expression of anti-inflammatory mediators. Additionally, it promotes the survival and function of various cell types, including endothelial cells, cardiomyocytes, and neurons, under stress conditions.
Research
Neuroprotection: ARA-290 has demonstrated neuroprotective properties in models of spinal cord injury, traumatic brain injury, and ischemic stroke, reducing neuronal damage and promoting functional recovery.
Cardioprotection: Studies have shown that ARA-290 can protect the heart from ischemia-reperfusion injury, reduce infarct size, and improve cardiac function in animal models of myocardial infarction.
Renal protection: ARA-290 has been found to attenuate renal injury and improve kidney function in preclinical models of acute kidney injury and chronic kidney disease.
Anti-inflammatory effects: The peptide exhibits potent anti-inflammatory properties, reducing the production of pro-inflammatory cytokines and promoting the resolution of inflammation in various tissues.
Wound healing: ARA-290 has been shown to accelerate wound healing and promote tissue repair in animal models of skin, corneal, and intestinal injuries.
Pain relief: Clinical studies have demonstrated that ARA-290 can effectively reduce neuropathic pain in patients with sarcoidosis and type 2 diabetes mellitus.
Side Effects
ARA-290 has been well-tolerated in clinical trials, with no significant side effects reported. Unlike EPO, ARA-290 does not stimulate erythropoiesis, minimizing the risk of thrombotic complications associated with increased red blood cell production.
Summary
ARA-290 is a promising synthetic peptide that mimics the tissue-protective and repair-promoting properties of EPO without stimulating erythropoiesis. By selectively activating the innate repair receptor, ARA-290 exerts potent anti-inflammatory, neuroprotective, cardioprotective, and renoprotective effects in various preclinical models. Clinical studies have also demonstrated its potential in reducing neuropathic pain and promoting wound healing. With its favorable safety profile and wide-ranging therapeutic potential, ARA-290 represents an exciting avenue for the development of novel treatments for a variety of conditions characterized by tissue damage and inflammation.
Characteristics
Molecular Formula
C225H348N60O68
CAS Number
2023788-19-2
Molar Mass
5047.61g/mol
Amino Acid
Sequence
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
Synonyms
LY3298176
Solubility
Water-soluble |
Organoleptic Profile
White to off-white powder
Composition
Lyophilized powder - requires reconstitution
How does ARA-290 work?
ARA-290 exerts its effects by selectively activating the innate repair receptor (IRR), a heteromeric complex composed of EPO receptor (EPOR) and β common receptor (βcR) subunits. This specific interaction triggers a cascade of signaling events that lead to anti-inflammatory, tissue-protective, and repair-promoting effects. ARA-290 has been shown to modulate the immune response by reducing the production of pro-inflammatory cytokines and increasing the expression of anti-inflammatory mediators. Additionally, it promotes the survival and function of various cell types, including endothelial cells, cardiomyocytes, and neurons, under stress conditions.
Research
Neuroprotection: ARA-290 has demonstrated neuroprotective properties in models of spinal cord injury, traumatic brain injury, and ischemic stroke, reducing neuronal damage and promoting functional recovery.
Cardioprotection: Studies have shown that ARA-290 can protect the heart from ischemia-reperfusion injury, reduce infarct size, and improve cardiac function in animal models of myocardial infarction.
Renal protection: ARA-290 has been found to attenuate renal injury and improve kidney function in preclinical models of acute kidney injury and chronic kidney disease.
Anti-inflammatory effects: The peptide exhibits potent anti-inflammatory properties, reducing the production of pro-inflammatory cytokines and promoting the resolution of inflammation in various tissues.
Wound healing: ARA-290 has been shown to accelerate wound healing and promote tissue repair in animal models of skin, corneal, and intestinal injuries.
Pain relief: Clinical studies have demonstrated that ARA-290 can effectively reduce neuropathic pain in patients with sarcoidosis and type 2 diabetes mellitus.
Side Effects
ARA-290 has been well-tolerated in clinical trials, with no significant side effects reported. Unlike EPO, ARA-290 does not stimulate erythropoiesis, minimizing the risk of thrombotic complications associated with increased red blood cell production.
Summary
ARA-290 is a promising synthetic peptide that mimics the tissue-protective and repair-promoting properties of EPO without stimulating erythropoiesis. By selectively activating the innate repair receptor, ARA-290 exerts potent anti-inflammatory, neuroprotective, cardioprotective, and renoprotective effects in various preclinical models. Clinical studies have also demonstrated its potential in reducing neuropathic pain and promoting wound healing. With its favorable safety profile and wide-ranging therapeutic potential, ARA-290 represents an exciting avenue for the development of novel treatments for a variety of conditions characterized by tissue damage and inflammation.
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All products on this site are intended for research and development purposes only and are not meant for human consumption of any kind. Neither the statements nor the products offered by this company are intended to diagnose, treat, cure, or prevent any disease.
© 2025, Peptide Supplied™. All Rights Reserved.
Subscribe to our newsletter
Receive weekly updates with the newest insights, trends, and tools, straight to your email.
PEPTIDE
SUPPLIED
Contact Us
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Company
All products on this site are intended for research and development purposes only and are not meant for human consumption of any kind. Neither the statements nor the products offered by this company are intended to diagnose, treat, cure, or prevent any disease.
© 2025, Peptide Supplied™. All Rights Reserved.