Product Usage: This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals. It is not approved for human or animal consumption. Misuse, misbranding, or mislabeling as a drug, food, or cosmetic is strictly prohibited. All information provided is for educational purposes only.
NAD+
£199.99
In stock
Nicotinamide adenine dinucleotide (NAD+) is a crucial coenzyme that plays a vital role in energy metabolism, DNA repair, cell signaling, and aging. Research suggests that maintaining optimal NAD+ levels through supplementation with precursors like nicotinic acid, nicotinamide, and nicotinamide riboside may provide benefits for longevity, metabolic health, cardiovascular function, neurological health, DNA repair, and inflammation. While generally safe, NAD+ precursors should be used under medical supervision to avoid potential side effects at high doses. More human studies are needed to fully understand the therapeutic potential of NAD+ supplementation for promoting health and longevity. **Storage: 2C to 8C and away from light. Requires reconstitution before use.
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Size:
500 mg
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NAD+
£199.99
In stock
Buy 3+ for £50 each and save 5%
Buy 5+ for £50 each and save 8%
Buy 10+ for £50 each and save 10%
Loading stock...
Size:
500 mg
Ships tomorrow morning if ordered by 2PM UTC
Free international delivery within 1-3 business days on orders over £250, with a tracking number provided.
Third party tested
FREE Bacteriostatic Water
For every £75 you spend, get 1 FREE bottle of Bacteriostatic Water to reconstitute your peptides.
Nicotinamide adenine dinucleotide (NAD+) is a crucial coenzyme that plays a vital role in energy metabolism, DNA repair, cell signaling, and aging. Research suggests that maintaining optimal NAD+ levels through supplementation with precursors like nicotinic acid, nicotinamide, and nicotinamide riboside may provide benefits for longevity, metabolic health, cardiovascular function, neurological health, DNA repair, and inflammation. While generally safe, NAD+ precursors should be used under medical supervision to avoid potential side effects at high doses. More human studies are needed to fully understand the therapeutic potential of NAD+ supplementation for promoting health and longevity. **Storage: 2C to 8C and away from light. Requires reconstitution before use.
Product Usage: This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals. It is not approved for human or animal consumption. Misuse, misbranding, or mislabeling as a drug, food, or cosmetic is strictly prohibited. All information provided is for educational purposes only.
Characteristics
Molecular Formula
C225H348N60O68
CAS Number
2023788-19-2
Molar Mass
5047.61g/mol
Amino Acid
Sequence
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
Synonyms
LY3298176
Solubility
Water-soluble |
Organoleptic Profile
White to off-white powder
Composition
Lyophilized powder - requires reconstitution
How does NAD+ work?
NAD+ acts as a critical coenzyme in redox reactions, accepting or donating electrons in metabolic pathways such as glycolysis, fatty acid oxidation, and the citric acid cycle. It is a substrate for sirtuins, NAD+-dependent deacetylases that remove acetyl groups from proteins and regulate gene expression. Sirtuins are involved in DNA repair, stress resistance, inflammation, and metabolic homeostasis. NAD+ is also consumed by poly(ADP-ribose) polymerases (PARPs) in response to DNA damage. PARPs help repair DNA but can deplete NAD+ levels if overactivated. CD38, an enzyme that generates cyclic ADP-ribose, also consumes NAD+. NAD+ can be synthesized de novo from the amino acid tryptophan or through salvage pathways using precursors like nicotinic acid, nicotinamide, and nicotinamide riboside. Supplementing with these precursors can boost NAD+ levels.
Research
Research suggests that maintaining optimal NAD+ levels may provide the following benefits:
Longevity: Studies in yeast, worms, and mice have shown that boosting NAD+ levels can extend lifespan. Sirtuins, which are NAD+-dependent, are linked to increased longevity in various organisms.
Metabolic health: NAD+ is crucial for energy metabolism. Increasing NAD+ levels can improve mitochondrial function, glucose metabolism, and insulin sensitivity. It may help protect against obesity, type 2 diabetes, and metabolic syndrome.
Cardiovascular health: NAD+ precursors have shown potential benefits for cardiovascular health, such as improving blood pressure, reducing inflammation, and protecting against oxidative stress.
Neurological health: NAD+ is important for neuronal function and energy metabolism in the brain. Boosting NAD+ levels may help protect against age-related cognitive decline, Alzheimer's disease, and Parkinson's disease.
DNA repair: NAD+ is a substrate for PARPs, which are involved in repairing DNA damage. Maintaining adequate NAD+ levels may support DNA repair mechanisms and genomic stability.
Inflammation: Sirtuins, which are NAD+-dependent, have anti-inflammatory effects. Increasing NAD+ levels may help regulate inflammation and protect against chronic inflammatory diseases.
Side Effects
NAD+ precursors like nicotinic acid, nicotinamide, and nicotinamide riboside are generally well-tolerated. However, high doses of nicotinic acid can cause flushing, itching, and gastrointestinal discomfort. Nicotinamide at high doses may also cause gastrointestinal side effects and liver toxicity.
Summary
NAD+ is a vital coenzyme involved in energy metabolism, DNA repair, cell signalling, and aging. Maintaining optimal NAD+ levels through supplementation with precursors or other means may provide benefits for longevity, metabolic health, cardiovascular health, neurological function, DNA repair, and inflammation. While NAD+ precursors are generally safe, it is important to use them under medical supervision and be aware of potential side effects at high doses.
Characteristics
Molecular Formula
C225H348N60O68
CAS Number
2023788-19-2
Molar Mass
5047.61g/mol
Amino Acid
Sequence
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
Synonyms
LY3298176
Solubility
Water-soluble |
Organoleptic Profile
White to off-white powder
Composition
Lyophilized powder - requires reconstitution
How does NAD+ work?
NAD+ acts as a critical coenzyme in redox reactions, accepting or donating electrons in metabolic pathways such as glycolysis, fatty acid oxidation, and the citric acid cycle. It is a substrate for sirtuins, NAD+-dependent deacetylases that remove acetyl groups from proteins and regulate gene expression. Sirtuins are involved in DNA repair, stress resistance, inflammation, and metabolic homeostasis. NAD+ is also consumed by poly(ADP-ribose) polymerases (PARPs) in response to DNA damage. PARPs help repair DNA but can deplete NAD+ levels if overactivated. CD38, an enzyme that generates cyclic ADP-ribose, also consumes NAD+. NAD+ can be synthesized de novo from the amino acid tryptophan or through salvage pathways using precursors like nicotinic acid, nicotinamide, and nicotinamide riboside. Supplementing with these precursors can boost NAD+ levels.
Research
Research suggests that maintaining optimal NAD+ levels may provide the following benefits:
Longevity: Studies in yeast, worms, and mice have shown that boosting NAD+ levels can extend lifespan. Sirtuins, which are NAD+-dependent, are linked to increased longevity in various organisms.
Metabolic health: NAD+ is crucial for energy metabolism. Increasing NAD+ levels can improve mitochondrial function, glucose metabolism, and insulin sensitivity. It may help protect against obesity, type 2 diabetes, and metabolic syndrome.
Cardiovascular health: NAD+ precursors have shown potential benefits for cardiovascular health, such as improving blood pressure, reducing inflammation, and protecting against oxidative stress.
Neurological health: NAD+ is important for neuronal function and energy metabolism in the brain. Boosting NAD+ levels may help protect against age-related cognitive decline, Alzheimer's disease, and Parkinson's disease.
DNA repair: NAD+ is a substrate for PARPs, which are involved in repairing DNA damage. Maintaining adequate NAD+ levels may support DNA repair mechanisms and genomic stability.
Inflammation: Sirtuins, which are NAD+-dependent, have anti-inflammatory effects. Increasing NAD+ levels may help regulate inflammation and protect against chronic inflammatory diseases.
Side Effects
NAD+ precursors like nicotinic acid, nicotinamide, and nicotinamide riboside are generally well-tolerated. However, high doses of nicotinic acid can cause flushing, itching, and gastrointestinal discomfort. Nicotinamide at high doses may also cause gastrointestinal side effects and liver toxicity.
Summary
NAD+ is a vital coenzyme involved in energy metabolism, DNA repair, cell signalling, and aging. Maintaining optimal NAD+ levels through supplementation with precursors or other means may provide benefits for longevity, metabolic health, cardiovascular health, neurological function, DNA repair, and inflammation. While NAD+ precursors are generally safe, it is important to use them under medical supervision and be aware of potential side effects at high doses.
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All products on this site are intended for research and development purposes only and are not meant for human consumption of any kind. Neither the statements nor the products offered by this company are intended to diagnose, treat, cure, or prevent any disease.
© 2025, Peptide Supplied™. All Rights Reserved.
Subscribe to our newsletter
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PEPTIDE
SUPPLIED
Contact Us
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Company
All products on this site are intended for research and development purposes only and are not meant for human consumption of any kind. Neither the statements nor the products offered by this company are intended to diagnose, treat, cure, or prevent any disease.
© 2025, Peptide Supplied™. All Rights Reserved.