Product Usage: This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals. It is not approved for human or animal consumption. Misuse, misbranding, or mislabeling as a drug, food, or cosmetic is strictly prohibited. All information provided is for educational purposes only.
SS-31
£49.99
In stock
SS-31, also known as elamipretide, is a small mitochondrially-targeted tetrapeptide that has shown promising results in various research studies for its potential therapeutic benefits. This peptide is designed to penetrate the mitochondrial membrane and protect against oxidative stress, inflammation, and mitochondrial dysfunction. SS-31 has been investigated for its neuroprotective, cardioprotective, and anti-aging properties, making it a potential candidate for the treatment of various age-related and neurodegenerative disorders. Requires reconstitution before use.
Loading stock...
Size:
10 mg
Ships tomorrow morning if ordered by 2PM UTC
Free international delivery within 1-3 business days on orders over £250, with a tracking number provided.
Third party tested
FREE Bacteriostatic Water
For every £75 you spend, get 1 FREE bottle of Bacteriostatic Water to reconstitute your peptides.
SS-31
£49.99
In stock
Buy 3+ for £50 each and save 5%
Buy 5+ for £50 each and save 8%
Buy 10+ for £50 each and save 10%
Loading stock...
Size:
10 mg
Ships tomorrow morning if ordered by 2PM UTC
Free international delivery within 1-3 business days on orders over £250, with a tracking number provided.
Third party tested
FREE Bacteriostatic Water
For every £75 you spend, get 1 FREE bottle of Bacteriostatic Water to reconstitute your peptides.
SS-31, also known as elamipretide, is a small mitochondrially-targeted tetrapeptide that has shown promising results in various research studies for its potential therapeutic benefits. This peptide is designed to penetrate the mitochondrial membrane and protect against oxidative stress, inflammation, and mitochondrial dysfunction. SS-31 has been investigated for its neuroprotective, cardioprotective, and anti-aging properties, making it a potential candidate for the treatment of various age-related and neurodegenerative disorders. Requires reconstitution before use.
Product Usage: This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals. It is not approved for human or animal consumption. Misuse, misbranding, or mislabeling as a drug, food, or cosmetic is strictly prohibited. All information provided is for educational purposes only.
Characteristics
Molecular Formula
C225H348N60O68
CAS Number
2023788-19-2
Molar Mass
5047.61g/mol
Amino Acid
Sequence
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
Synonyms
LY3298176
Solubility
Water-soluble |
Organoleptic Profile
White to off-white powder
Composition
Lyophilized powder - requires reconstitution
How does SS-31 work?
SS-31 targets the inner mitochondrial membrane, where it binds to cardiolipin, a phospholipid essential for maintaining mitochondrial structure and function. By stabilizing cardiolipin, SS-31 helps to preserve the integrity of the mitochondrial membrane and enhances the efficiency of the electron transport chain. This, in turn, reduces the production of reactive oxygen species (ROS) and improves overall mitochondrial function. Additionally, SS-31 has been shown to modulate various signaling pathways involved in inflammation, apoptosis, and cellular stress responses. It can inhibit the activation of pro-inflammatory cytokines, such as TNF-α and IL-1β, and reduce the expression of apoptotic markers, like caspase-3 and Bax. SS-31 also promotes the activation of pro-survival pathways, including the PI3K/Akt and MAPK/ERK signaling cascades, which contribute to its cytoprotective effects.
Research
Neuroprotection: SS-31 has demonstrated neuroprotective properties in various animal models of neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and traumatic brain injury. It can reduce oxidative stress, inflammation, and mitochondrial dysfunction in the brain, leading to improved cognitive function and reduced neuronal damage.
Cardioprotection: Studies have shown that SS-31 can protect the heart from ischemia-reperfusion injury, reduce cardiac hypertrophy, and improve cardiac function in models of heart failure. By preserving mitochondrial function and reducing oxidative stress, SS-31 may have potential therapeutic applications in cardiovascular diseases.
Anti-aging effects: SS-31 has been investigated for its potential to attenuate age-related changes in various tissues, including the heart, skeletal muscle, and brain. It can reduce age-associated post-translational modifications of proteins, improve mitochondrial function, and enhance cellular resilience, suggesting its potential as an anti-aging intervention.
Mitochondrial myopathy: In a randomized clinical trial (MMPOWER-3), SS-31 demonstrated efficacy and safety in individuals with primary mitochondrial myopathy. The peptide improved exercise tolerance, walking distance, and overall quality of life in patients, highlighting its potential as a treatment for mitochondrial disorders.
Retinal diseases: SS-31 has shown promise in preclinical studies for the treatment of age-related macular degeneration (AMD) and other retinal disorders. By reducing oxidative stress and preserving mitochondrial function in the retina, SS-31 may help to prevent or slow the progression of these diseases.
Side Effects
In clinical trials and preclinical studies, SS-31 has been generally well-tolerated, with no significant adverse effects reported. However, as with any investigational compound, further research is needed to fully evaluate its safety profile and potential long-term side effects.
Summary
SS-31 (elamipretide) is a mitochondrially-targeted peptide that has shown promising therapeutic potential in various research studies. By stabilizing cardiolipin, reducing oxidative stress, and modulating inflammatory and apoptotic pathways, SS-31 can protect against mitochondrial dysfunction and cellular damage. Its neuroprotective, cardioprotective, and anti-aging properties make it a potential candidate for the treatment of age-related and neurodegenerative disorders, as well as mitochondrial myopathies and retinal diseases. While further clinical studies are needed to fully evaluate its efficacy and safety, SS-31 represents an exciting avenue for the development of novel therapies targeting mitochondrial dysfunction.
Characteristics
Molecular Formula
C225H348N60O68
CAS Number
2023788-19-2
Molar Mass
5047.61g/mol
Amino Acid
Sequence
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
Synonyms
LY3298176
Solubility
Water-soluble |
Organoleptic Profile
White to off-white powder
Composition
Lyophilized powder - requires reconstitution
How does SS-31 work?
SS-31 targets the inner mitochondrial membrane, where it binds to cardiolipin, a phospholipid essential for maintaining mitochondrial structure and function. By stabilizing cardiolipin, SS-31 helps to preserve the integrity of the mitochondrial membrane and enhances the efficiency of the electron transport chain. This, in turn, reduces the production of reactive oxygen species (ROS) and improves overall mitochondrial function. Additionally, SS-31 has been shown to modulate various signaling pathways involved in inflammation, apoptosis, and cellular stress responses. It can inhibit the activation of pro-inflammatory cytokines, such as TNF-α and IL-1β, and reduce the expression of apoptotic markers, like caspase-3 and Bax. SS-31 also promotes the activation of pro-survival pathways, including the PI3K/Akt and MAPK/ERK signaling cascades, which contribute to its cytoprotective effects.
Research
Neuroprotection: SS-31 has demonstrated neuroprotective properties in various animal models of neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and traumatic brain injury. It can reduce oxidative stress, inflammation, and mitochondrial dysfunction in the brain, leading to improved cognitive function and reduced neuronal damage.
Cardioprotection: Studies have shown that SS-31 can protect the heart from ischemia-reperfusion injury, reduce cardiac hypertrophy, and improve cardiac function in models of heart failure. By preserving mitochondrial function and reducing oxidative stress, SS-31 may have potential therapeutic applications in cardiovascular diseases.
Anti-aging effects: SS-31 has been investigated for its potential to attenuate age-related changes in various tissues, including the heart, skeletal muscle, and brain. It can reduce age-associated post-translational modifications of proteins, improve mitochondrial function, and enhance cellular resilience, suggesting its potential as an anti-aging intervention.
Mitochondrial myopathy: In a randomized clinical trial (MMPOWER-3), SS-31 demonstrated efficacy and safety in individuals with primary mitochondrial myopathy. The peptide improved exercise tolerance, walking distance, and overall quality of life in patients, highlighting its potential as a treatment for mitochondrial disorders.
Retinal diseases: SS-31 has shown promise in preclinical studies for the treatment of age-related macular degeneration (AMD) and other retinal disorders. By reducing oxidative stress and preserving mitochondrial function in the retina, SS-31 may help to prevent or slow the progression of these diseases.
Side Effects
In clinical trials and preclinical studies, SS-31 has been generally well-tolerated, with no significant adverse effects reported. However, as with any investigational compound, further research is needed to fully evaluate its safety profile and potential long-term side effects.
Summary
SS-31 (elamipretide) is a mitochondrially-targeted peptide that has shown promising therapeutic potential in various research studies. By stabilizing cardiolipin, reducing oxidative stress, and modulating inflammatory and apoptotic pathways, SS-31 can protect against mitochondrial dysfunction and cellular damage. Its neuroprotective, cardioprotective, and anti-aging properties make it a potential candidate for the treatment of age-related and neurodegenerative disorders, as well as mitochondrial myopathies and retinal diseases. While further clinical studies are needed to fully evaluate its efficacy and safety, SS-31 represents an exciting avenue for the development of novel therapies targeting mitochondrial dysfunction.
Subscribe to our newsletter
Receive weekly updates with the newest insights, trends, and tools, straight to your email.
PEPTIDE
SUPPLIED
Contact Us
Email:
support@peptidesupplied.com
Peptides
Company
All products on this site are intended for research and development purposes only and are not meant for human consumption of any kind. Neither the statements nor the products offered by this company are intended to diagnose, treat, cure, or prevent any disease.
© 2025, Peptide Supplied™. All Rights Reserved.
Subscribe to our newsletter
Receive weekly updates with the newest insights, trends, and tools, straight to your email.
PEPTIDE
SUPPLIED
Contact Us
Email:
support@peptidesupplied.com
Peptides
Anti-Aging
Anti-Inflammatory
Cardiovascular Health
Endocrinology
Energy Support
Immunomodulator
Longevity
Metabolic Regulation
Nootropic
Reproductive Health
Sleep/Circadian Rhythm
Tissue Repair & Regeneration
Weight Management
Company
All products on this site are intended for research and development purposes only and are not meant for human consumption of any kind. Neither the statements nor the products offered by this company are intended to diagnose, treat, cure, or prevent any disease.
© 2025, Peptide Supplied™. All Rights Reserved.