Product Usage: This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals. It is not approved for human or animal consumption. Misuse, misbranding, or mislabeling as a drug, food, or cosmetic is strictly prohibited. All information provided is for educational purposes only.
VIP
£49.99
In stock
Vasoactive Intestinal Peptide (VIP) is a neuropeptide hormone composed of 28 amino acid residues. It is widely distributed in the central and peripheral nervous systems, as well as in the digestive, respiratory, reproductive, and cardiovascular systems. VIP exhibits a range of biological functions, including vasodilation, smooth muscle relaxation, secretion regulation, and immunomodulation. As a neurotransmitter and neuromodulator, VIP plays a crucial role in maintaining homeostasis and has shown potential therapeutic applications in various disorders, such as inflammatory diseases, neurodegenerative conditions, and cancer. Requires reconstitution before use.
Loading stock...
Size:
5 mg
Ships tomorrow morning if ordered by 2PM UTC
Free international delivery within 1-3 business days on orders over £250, with a tracking number provided.
Third party tested
FREE Bacteriostatic Water
For every £75 you spend, get 1 FREE bottle of Bacteriostatic Water to reconstitute your peptides.
VIP
£49.99
In stock
Buy 3+ for £50 each and save 5%
Buy 5+ for £50 each and save 8%
Buy 10+ for £50 each and save 10%
Loading stock...
Size:
5 mg
Ships tomorrow morning if ordered by 2PM UTC
Free international delivery within 1-3 business days on orders over £250, with a tracking number provided.
Third party tested
FREE Bacteriostatic Water
For every £75 you spend, get 1 FREE bottle of Bacteriostatic Water to reconstitute your peptides.
Vasoactive Intestinal Peptide (VIP) is a neuropeptide hormone composed of 28 amino acid residues. It is widely distributed in the central and peripheral nervous systems, as well as in the digestive, respiratory, reproductive, and cardiovascular systems. VIP exhibits a range of biological functions, including vasodilation, smooth muscle relaxation, secretion regulation, and immunomodulation. As a neurotransmitter and neuromodulator, VIP plays a crucial role in maintaining homeostasis and has shown potential therapeutic applications in various disorders, such as inflammatory diseases, neurodegenerative conditions, and cancer. Requires reconstitution before use.
Product Usage: This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals. It is not approved for human or animal consumption. Misuse, misbranding, or mislabeling as a drug, food, or cosmetic is strictly prohibited. All information provided is for educational purposes only.
Characteristics
Molecular Formula
C225H348N60O68
CAS Number
2023788-19-2
Molar Mass
5047.61g/mol
Amino Acid
Sequence
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
Synonyms
LY3298176
Solubility
Water-soluble |
Organoleptic Profile
White to off-white powder
Composition
Lyophilized powder - requires reconstitution
How does VIP work?
VIP exerts its effects by binding to specific G protein-coupled receptors, namely VPAC1 and VPAC2. These receptors are expressed in various tissues, including the brain, lungs, intestines, and immune cells. Upon binding, VIP activates adenylate cyclase, leading to an increase in intracellular cyclic AMP (cAMP) levels. This, in turn, triggers a cascade of signaling events that regulate diverse physiological processes. VIP's vasodilatory effects are mediated through the relaxation of smooth muscle cells in blood vessels, resulting in increased blood flow and reduced blood pressure. In the digestive system, VIP stimulates the secretion of water and electrolytes, promoting digestion and nutrient absorption. Additionally, VIP acts as a potent anti-inflammatory agent by inhibiting the production of pro-inflammatory cytokines and modulating the activity of immune cells, such as T lymphocytes and macrophages.
Research
Anti-inflammatory properties: VIP has demonstrated significant anti-inflammatory effects in various experimental models. It inhibits the production of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-12, while promoting the release of anti-inflammatory cytokines like IL-10. This makes VIP a promising candidate for the treatment of inflammatory disorders, including rheumatoid arthritis, inflammatory bowel disease, and sepsis.
Neuroprotection: VIP has shown neuroprotective properties in several studies. It protects neurons from oxidative stress, excitotoxicity, and apoptosis, which are common pathological processes in neurodegenerative diseases like Alzheimer's and Parkinson's. VIP also promotes neurogenesis, enhances synaptic plasticity, and improves cognitive function, suggesting its potential as a therapeutic agent for neurodegenerative disorders.
Immunomodulation: VIP plays a crucial role in regulating the immune system. It modulates the balance between T helper 1 (Th1) and T helper 2 (Th2) responses, favoring a shift towards the anti-inflammatory Th2 response. This immunomodulatory effect makes VIP a potential treatment for autoimmune diseases, such as multiple sclerosis and type 1 diabetes.
Cardiovascular protection: VIP's vasodilatory and anti-inflammatory properties contribute to its cardiovascular protective effects. It reduces blood pressure, improves endothelial function, and attenuates the development of atherosclerosis. VIP also exhibits cardioprotective effects in ischemia-reperfusion injury, reducing infarct size and preserving cardiac function.
Respiratory benefits: VIP has been shown to have bronchodilatory effects, making it a potential therapeutic target for respiratory disorders like asthma and chronic obstructive pulmonary disease (COPD). It relaxes airway smooth muscle, reduces airway inflammation, and promotes mucus secretion, improving overall respiratory function.
Gastrointestinal regulation: VIP is a key regulator of gastrointestinal function. It stimulates the secretion of water, electrolytes, and bicarbonate, promoting digestion and nutrient absorption. VIP also exhibits protective effects in gastrointestinal disorders, such as inflammatory bowel disease and colitis, by reducing inflammation and promoting mucosal healing.
Side Effects
While VIP has shown promising therapeutic potential, it is essential to consider potential side effects. Some reported side effects of VIP administration include:
Hypotension: Due to its potent vasodilatory effects, VIP may cause a significant decrease in blood pressure, leading to dizziness, lightheadedness, or fainting.
Gastrointestinal disturbances: VIP's effects on gastrointestinal secretion and motility may result in side effects such as diarrhea, abdominal cramps, and nausea.
Flushing: Administration of VIP may cause flushing, a sudden redness of the skin, particularly on the face and neck.
Headache: Some individuals may experience headaches following VIP administration, possibly due to its vasodilatory effects.
Summary
Vasoactive Intestinal Peptide (VIP) is a multifunctional neuropeptide with a wide range of biological effects, including vasodilation, smooth muscle relaxation, secretion regulation, and immunomodulation. Its anti-inflammatory, neuroprotective, immunomodulatory, cardiovascular protective, respiratory, and gastrointestinal regulatory properties make it a promising therapeutic target for various disorders. However, potential side effects, such as hypotension, gastrointestinal disturbances, flushing, and headache, should be considered when exploring VIP as a treatment option.
Characteristics
Molecular Formula
C225H348N60O68
CAS Number
2023788-19-2
Molar Mass
5047.61g/mol
Amino Acid
Sequence
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly
Synonyms
LY3298176
Solubility
Water-soluble |
Organoleptic Profile
White to off-white powder
Composition
Lyophilized powder - requires reconstitution
How does VIP work?
VIP exerts its effects by binding to specific G protein-coupled receptors, namely VPAC1 and VPAC2. These receptors are expressed in various tissues, including the brain, lungs, intestines, and immune cells. Upon binding, VIP activates adenylate cyclase, leading to an increase in intracellular cyclic AMP (cAMP) levels. This, in turn, triggers a cascade of signaling events that regulate diverse physiological processes. VIP's vasodilatory effects are mediated through the relaxation of smooth muscle cells in blood vessels, resulting in increased blood flow and reduced blood pressure. In the digestive system, VIP stimulates the secretion of water and electrolytes, promoting digestion and nutrient absorption. Additionally, VIP acts as a potent anti-inflammatory agent by inhibiting the production of pro-inflammatory cytokines and modulating the activity of immune cells, such as T lymphocytes and macrophages.
Research
Anti-inflammatory properties: VIP has demonstrated significant anti-inflammatory effects in various experimental models. It inhibits the production of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-12, while promoting the release of anti-inflammatory cytokines like IL-10. This makes VIP a promising candidate for the treatment of inflammatory disorders, including rheumatoid arthritis, inflammatory bowel disease, and sepsis.
Neuroprotection: VIP has shown neuroprotective properties in several studies. It protects neurons from oxidative stress, excitotoxicity, and apoptosis, which are common pathological processes in neurodegenerative diseases like Alzheimer's and Parkinson's. VIP also promotes neurogenesis, enhances synaptic plasticity, and improves cognitive function, suggesting its potential as a therapeutic agent for neurodegenerative disorders.
Immunomodulation: VIP plays a crucial role in regulating the immune system. It modulates the balance between T helper 1 (Th1) and T helper 2 (Th2) responses, favoring a shift towards the anti-inflammatory Th2 response. This immunomodulatory effect makes VIP a potential treatment for autoimmune diseases, such as multiple sclerosis and type 1 diabetes.
Cardiovascular protection: VIP's vasodilatory and anti-inflammatory properties contribute to its cardiovascular protective effects. It reduces blood pressure, improves endothelial function, and attenuates the development of atherosclerosis. VIP also exhibits cardioprotective effects in ischemia-reperfusion injury, reducing infarct size and preserving cardiac function.
Respiratory benefits: VIP has been shown to have bronchodilatory effects, making it a potential therapeutic target for respiratory disorders like asthma and chronic obstructive pulmonary disease (COPD). It relaxes airway smooth muscle, reduces airway inflammation, and promotes mucus secretion, improving overall respiratory function.
Gastrointestinal regulation: VIP is a key regulator of gastrointestinal function. It stimulates the secretion of water, electrolytes, and bicarbonate, promoting digestion and nutrient absorption. VIP also exhibits protective effects in gastrointestinal disorders, such as inflammatory bowel disease and colitis, by reducing inflammation and promoting mucosal healing.
Side Effects
While VIP has shown promising therapeutic potential, it is essential to consider potential side effects. Some reported side effects of VIP administration include:
Hypotension: Due to its potent vasodilatory effects, VIP may cause a significant decrease in blood pressure, leading to dizziness, lightheadedness, or fainting.
Gastrointestinal disturbances: VIP's effects on gastrointestinal secretion and motility may result in side effects such as diarrhea, abdominal cramps, and nausea.
Flushing: Administration of VIP may cause flushing, a sudden redness of the skin, particularly on the face and neck.
Headache: Some individuals may experience headaches following VIP administration, possibly due to its vasodilatory effects.
Summary
Vasoactive Intestinal Peptide (VIP) is a multifunctional neuropeptide with a wide range of biological effects, including vasodilation, smooth muscle relaxation, secretion regulation, and immunomodulation. Its anti-inflammatory, neuroprotective, immunomodulatory, cardiovascular protective, respiratory, and gastrointestinal regulatory properties make it a promising therapeutic target for various disorders. However, potential side effects, such as hypotension, gastrointestinal disturbances, flushing, and headache, should be considered when exploring VIP as a treatment option.
Subscribe to our newsletter
Receive weekly updates with the newest insights, trends, and tools, straight to your email.
PEPTIDE
SUPPLIED
Contact Us
Email:
support@peptidesupplied.com
Peptides
Company
All products on this site are intended for research and development purposes only and are not meant for human consumption of any kind. Neither the statements nor the products offered by this company are intended to diagnose, treat, cure, or prevent any disease.
© 2025, Peptide Supplied™. All Rights Reserved.
Subscribe to our newsletter
Receive weekly updates with the newest insights, trends, and tools, straight to your email.
PEPTIDE
SUPPLIED
Contact Us
Email:
support@peptidesupplied.com
Peptides
Anti-Aging
Anti-Inflammatory
Cardiovascular Health
Endocrinology
Energy Support
Immunomodulator
Longevity
Metabolic Regulation
Nootropic
Reproductive Health
Sleep/Circadian Rhythm
Tissue Repair & Regeneration
Weight Management
Company
All products on this site are intended for research and development purposes only and are not meant for human consumption of any kind. Neither the statements nor the products offered by this company are intended to diagnose, treat, cure, or prevent any disease.
© 2025, Peptide Supplied™. All Rights Reserved.